Gold(III) Complexes for Antitumor Applications: An Overview.

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ID: 95439
2018
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Ranked #17 of 117 articles by views in Chemistry (Weinheim an der Bergstrasse, Germany)

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Abstract
Gold(III) complexes have emerged as a versatile and effective class of metal-based anticancer agents. The development of various types of ligands capable of stabilizing the Au cation and preventing its reduction under physiological conditions, such as chelating nitrogen-donors, dithiocarbamates and C^N cyclometalled ligands, has opened the way for the exploration of their potential intracellular targets and action mechanisms. At the same time, the bioconjugation of Au complexes has emerged as a promising strategy for improving the selectivity of this class of compounds for cancer cells over healthy tissues, and recent developments have shown that combining gold complexes with molecular structures that are specifically recognized by the cell can exploit the cell's own transport mechanisms to improve selective metal uptake.
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bertrand2018goldiiichemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Bertrand, Benoît;Williams, Morwen R M;Bochmann, Manfred;
Journal Chemistry (Weinheim an der Bergstrasse, Germany)
Year 2018
DOI
10.1002/chem.201800981
URL
Keywords
Cancer gold antitumor agents bioinorganic chemistry pincer ligands

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