On the oxidative damage by cadmium to kidney mitochondrial functions.

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ID: 95433
2019
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Abstract
In the kidney, the accumulation of heavy metals such as Cd produces mitochondrial dysfunctions, i.e., uncoupling of the oxidative phosphorylation, inhibition of the electron transport through the respiratory chain, and collapse of the transmembrane electrical gradient. This derangement may be due to the fact that Cd induces the transition of membrane permeability from selective to nonselective via the opening of a transmembrane pore. In fact, Cd produces this injury through the stimulation of oxygen-derived radical generation, inducing oxidative stress. Several molecules have been used to avoid or even reverse Cd-induced mitochondrial injury, for instance, cyclosporin A, resveratrol, dithiocarbamates, and even EDTA. The aim of this study was to explore the possibility that the antioxidant tamoxifen could protect mitochondria from the deleterious effects of Cd. Our results indicate that the addition of 1 μmol/L Cd to mitochondria collapsed the transmembrane electrical gradient, induced the release of cytochrome c, and increased both the generation of HO and the oxidative damage to mitochondrial DNA (among other measured parameters). Of interest, these mitochondrial dysfunctions were ameliorated after the addition of tamoxifen.
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pavn2019onbiochemistry Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pavón, Natalia;Buelna-Chontal, Mabel;Macías-López, Arturo;Correa, Francisco;Uribe-Álvarez, Cristina;Hernández-Esquivel, Luz;Chávez, Edmundo;
Journal biochemistry and cell biology = biochimie et biologie cellulaire
Year 2019
DOI
10.1139/bcb-2018-0196
URL
Keywords
oxidative stress kidney cadmium mitochondria mitochondrie permeability transition rein stress oxydant transition de perméabilité

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