A Comprehensive Nuclear Receptor Network for Breast Cancer Cells

Clicks: 168
ID: 95357
2013
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Abstract
In breast cancer, nuclear receptors (NRs) play a prominent role in governing gene expression, have prognostic utility, and are therapeutic targets. We built a regulatory map for 24 NRs, six chromatin state markers, and 14 breast-cancer-associated transcription factors (TFs) that are expressed in the breast cancer cell line MCF-7. The resulting network reveals a highly interconnected regulatory matrix where extensive crosstalk occurs among NRs and other breast -cancer-associated TFs. We show that large numbers of factors are coordinately bound to highly occupied target regions throughout the genome, and these regions are associated with active chromatin state and hormone-responsive gene expression. This network also provides a framework for stratifying and predicting patient outcomes, and we use it to show that the peroxisome proliferator-activated receptor delta binds to a set of genes also regulated by the retinoic acid receptors and whose expression is associated with poor prognosis in breast cancer.
Reference Key
kittler2013acell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kittler, Ralf;Zhou, Jie;Hua, Sujun;Ma, Lijia;Liu, Yuwen;Pendleton, Elisha;Cheng, Chao;Gerstein, Mark;White, Kevin P.;
Journal Cell reports
Year 2013
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S2211124713000119
Keywords
Biology (General) Medicine (General) Medicine neoplasms. tumors. oncology. including cancer and carcinogens public aspects of medicine

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