Synthesis of Functionalized Cannabilactones.
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2020
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Abstract
A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions.
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liu2020synthesismolecules
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| Authors | Liu, Yingpeng;Ho, Thanh C;Baradwan, Mohammed;Pascual Lopez-Alberca, Maria;Iliopoulos-Tsoutsouvas, Christos;Nikas, Spyros P;Makriyannis, Alexandros; |
| Journal | molecules |
| Year | 2020 |
| DOI |
E684
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