Synthesis of Functionalized Cannabilactones.

Clicks: 378
ID: 94790
2020
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Abstract
A new approach to synthesize cannabilactones using Suzuki cross-coupling reaction followed by one-step demethylation-cyclization is presented. The two key cannabilactone prototypes AM1710 and AM1714 were obtained selectively in high overall yields and in a lesser number of synthetic steps when compared to our earlier synthesis. The new approach expedited the synthesis of cannabilactone analogs with structural modifications at the four potential pharmacophoric regions.
Reference Key
liu2020synthesismolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liu, Yingpeng;Ho, Thanh C;Baradwan, Mohammed;Pascual Lopez-Alberca, Maria;Iliopoulos-Tsoutsouvas, Christos;Nikas, Spyros P;Makriyannis, Alexandros;
Journal molecules
Year 2020
DOI
E684
URL
Keywords
cannabinoids cb2 selective ligands suzuki cross-coupling cannabilactones

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