Mechanical and biocorrosive properties of magnesium-aluminum alloy scaffold for biomedical applications.

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ID: 94734
2019
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Abstract
This study investigates the morphology, microstructure, compressive behavior, biocorrosion properties, and cytocompatibility of magnesium (Mg)-aluminum (Al) alloy (AE42) scaffolds for their potential use in biodegradable biomedical applications. Mg alloy scaffolds were successfully synthesized via a camphene-based freeze-casting process with precisely controlled heat treatment. The average porosity was approximately 52% and the median pore diameter was ∼13 μm. Salient deformation mechanisms were identified using acoustic emission (AE) signals and adaptive sequential k-means (ASK) analysis. Twinning, dislocation slip, strut bending, and collapse were dominant during compressive deformation. Nonetheless, the overall compressive behavior and deformation mechanisms were similar to those of bulk Mg based on ASK analysis. The corrosion potential of the Mg alloy scaffold (-1.44 V) was slightly higher than that of bulk AE42 (-1.60 V), but the corrosion rate of the Mg alloy scaffold was faster than that of bulk AE42 due to the enhanced surface area of the Mg alloy scaffold. As a result of cytocompatibility evaluation following ISO10993-5, the concentration of the Mg alloy scaffold extract reducing cell growth rate to 50% (IC) was 10.7%, which is higher (less toxic) than 5%, suggesting no severe inflammation by implantation into muscle.
Reference Key
hong2019mechanicaljournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hong, Kicheol;Park, Hyeji;Kim, Yunsung;Knapek, Michal;Minárik, Peter;Máthis, Kristián;Yamamoto, Akiko;Choe, Heeman;
Journal Journal of the mechanical behavior of biomedical materials
Year 2019
DOI
S1751-6161(18)31168-8
URL
Keywords
Cytotoxicity mechanical properties powder metallurgy freeze casting biomedical application electrochemical impedance spectrometry porous magnesium

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