Gene manipulation to test links between genome, brain and behavior in developing songbirds: a test case.

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ID: 94499
2020
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Abstract
Songbird research has made many seminal contributions to the fields of ethology, endocrinology, physiology, ecology, evolution and neurobiology. Genome manipulation is thus a promising new methodological strategy to enhance the existing strengths of the songbird system to advance and expand fundamental knowledge of how genetic sequences and regulation of genomic function support complex natural learned behaviors. In zebra finches () in particular, a rich set of questions about the complex process of developmental song learning in juvenile males has been defined. This Review uses one area of zebra finch song learning to demonstrate how genome editing can advance causal investigations into known genome-brain-behavior relationships. Given the number and diversity of songbird species, comparative work leveraging genome manipulation would expand the influence of these birds in additional fields of ecology and evolution for song learning and other behaviors.
Reference Key
london2020genethe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors London, Sarah E;
Journal the journal of experimental biology
Year 2020
DOI
jeb206516
URL
Keywords
crispr brain development learning and memory critical period sensitive period zebra finch

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