Responsive functionalized MoSe nanosystem for highly efficient synergistic therapy of breast cancer.

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ID: 94025
2020
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Abstract
The photothermal/photodynamic synergistic therapy is a promising tumor treatment, but developing nanosystems that achieve synchronous photothermal/photodynamic functions is still quite challenging. Here, we use a simple method to synthesize molybdenum selenide nanoparticles (MoSe NPs) with a photothermal effect as a carrier, and load a photosensitizer ICG to form a nanosystem (MoSe@ICG-PDA-HA)with dual photothermal/photodynamic functions under near-infrared irradiation. In addition, the surface modification of the nanosystem with acid-responsive release polydopamine (PDA) and tumor-targeted hyaluronic acid (HA) enhanced the stability of the photosensitizer ICG and the accumulation of ICG at tumor sites. The multicellular sphere assay simulated solid tumors and demonstrated that MoSe@ICG-PDA-HA could significantly inhibit the 4T1 cell growth. The anti-tumor experiments in tumor-bearing mice showed that MoSe@ICG-PDA-HA not only significantly inhibited the growth of 4T1 subcutaneous tumors, but also inhibited their metastasis. This study presented a nanosystem that could improve the photostability of optical materials and enhance the photothermal/photodynamic synergy effect, providing a new idea for finding a way to effectively treat breast cancer.
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liu2020responsivecolloids Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yanan Liu, Chunfang Wei, Ange Lin, Jiali Pan, Xu Chen, Xufeng Zhu, Youcong Gong, Guanglong Yuan, Lanmei Chen, Jie Liu, Zhaohui Luo
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Journal colloids and surfaces b, biointerfaces
Year 2020
DOI
S0927-7765(20)30050-3
URL
Keywords
Breast cancer photothermal therapy multimodal imaging photodynamic therapy photostability molybdenum selenide

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