Pharmacokinetics, Tissue Distribution, and Excretion Study of Cajanonic Acid A in Rats by UPLC-MS/MS.

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ID: 94004
2020
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Abstract
Cajanonic acid A (CAA), a prenylated stilbene derivative extracted from the leaves of pigeon pea (), has been reported to possess inhibitory activity on the peroxisome proliferator-activated receptor gamma (PPAR) and protein tyrosine phosphatase 1B (PTP1B). Its hypoglycemic activity in rats is comparable to that of the approved antidiabetic agent rosiglitazone. Therefore, CAA is a potential candidate for the treatment of type 2 diabetes and a lead compound for the discovery of novel hypoglycemic drugs. To achieve a thorough understanding of the biological behavior of CAA , our current study was designed to investigate the pharmacokinetics, bioavailability, distribution, and excretion of CAA in rats by UPLC-MS/MS. Chromatographic separation was performed on BEHC18 column (2.1 mm × 50 mm, 1.7 µm). Quantification was performed under the negative ion mode by using single reaction monitoring (SRM) of the transitions of 353.14 → 309.11 for CAA and 269.86 → 224.11 for genistein, respectively. Standard calibration curve showed excellent linearity (r > 0.99) within the range of 2 - 800 ng/mL. The accuracies and precisions were within the acceptance limits (all < 20%). CAA was quickly absorbed into bloodstream and distributed rapidly and widely to various tissues. The excretion ratio of CAA in the 3 main pathways via bile, feces, and urine was only 5.17%. These results indicate that CAA was quickly and thoroughly metabolized and excreted mainly as metabolites.
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zhang2020pharmacokineticsplanta Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Li;Chen, Rui;Ban, Yujuan;Cai, Jin;Peng, Jingang;Huang, Jing;Wang, Jianta;Chen, Wenzhang;Gao, Xiuli;Zhou, Xunrong;Tang, Lei;
Journal planta medica
Year 2020
DOI
10.1055/a-1106-6785
URL
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