Free Radical Scavenging, Antimicrobial and Immunomodulatory Activities of <em>Orthosiphon stamineus</em>

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ID: 93851
2012
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Abstract
<em>Orthosiphon stamineus </em>is considered an important traditional folk medicine. In this study ethanol and aqueous extracts of <em>O. stamineus</em> were evaluated<em> in vitro </em>for their antioxidant, antimicrobial as well as for their immunomodulatory properties on human peripheral blood mononuclear cells (PBMCs). The DPPH radical scavenging method was used for the determination of antioxidant activity, while the antibacterial efficacy was investigated by both disc diffusion method and Minimum Inhibitory Concentration (MIC) against four bacterial strains (Gram-positive and Gram-negative). Furthermore, the immunomodulatory potential of the extracts was investigated through the MTT assay. Aqueous extract <strong>of </strong><em>O. stamineus</em> exhibited significant free radical scavenging activity with IC<sub>50</sub> 9.6 µg/mL, whereas the IC<sub>50</sub> for the ethanol extract was 21.4 µg/mL. The best antimicrobial activity was shown by the aqueous extract of <em>O. stamineus </em>against <em>Staphylococcus aureus</em>, with inhibition zone of 10.5 mm and MIC value 1.56 mg/mL. Moreover, the results observed from the MTT assay showed that both plant extracts stimulated the PBMCs proliferation<em> in vitro</em> in a concentration-dependent manner, but the aqueous extract has remarkable activity against PBMCs. These findings indicate that <em>O. stamineus</em> showed high antioxidant activity and may be considered as an immunomodulatory agent.
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harmal2012freemolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Harmal, Nabil S.;Hadi, Hamid A.;Qader, Suhailah W.;Alshawsh, Mohammed A.;Ismail, Salmah;Amin, Zahra A.;Abdulla, Mahmood A.;
Journal molecules
Year 2012
DOI
DOI not found
URL
http://www.mdpi.com/1420-3049/17/5/5385
Keywords
Organic Chemistry Medicine nutrition. foods and food supply

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