Humoral Immunity vs. .

Clicks: 325
ID: 93646
2019
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Ranked #28 of 111 articles by views in Frontiers in immunology

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Abstract
In primary infection with , it has been reported-without consideration of 's functions-that humoral immunity plays no role in the clearance of bacteria. In fact, targets and suppresses several aspects of humoral immunity, including B cell lymphopoiesis, B cell activation, and IgG production. In particular, the suppression of IgG-secreting plasma cell maintenance allows the persistence of in tissues. Therefore, the critical role(s) of humoral immunity in the response to infection, especially at the late phase, should be re-investigated. The suppression of IgG plasma cell memory strongly hinders vaccine development against non-typhoidal (NTS) because can also reduce humoral immune memory against other bacteria and viruses, obtained from previous vaccination or infection. We propose a new vaccine against that would not impair humoral immunity, and which could also be used as a treatment for antibody-dependent autoimmune diseases to deplete pathogenic long-lived plasma cells, by utilizing the 's own suppression mechanism of humoral immunity.
Reference Key
takaya2019humoralfrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Takaya, Akiko;Yamamoto, Tomoko;Tokoyoda, Koji;
Journal Frontiers in immunology
Year 2019
DOI
10.3389/fimmu.2019.03155
URL
Keywords
antibody salmonella humoral immunity igg plasma cells

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