Deposition of catechol-functionalized chitosan and silver nanoparticles on biomedical titanium surfaces for antibacterial application.

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ID: 932
2019
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Ranked #6 of 133 articles by views in materials science & engineering c, materials for biological applications

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Abstract
The titanium (Ti) and its alloys have been widely used for dental and orthopedic implants. However, the Ti-based implants may suffer from bacterial infection, which would result in insufficient healing, implant failure and repeated surgical intervention. It is of great interest to inhibit the bacterial adhesion and colonization on the Ti-based implants by introducing proper surface coatings. In this work, a simple method was employed to synthesize the water-soluble catechol-containing chitosan (CACS). The CACS coatings can be deposited onto various substrate surfaces and exhibit substrate-independent behavior. The CACS-coated Ti surfaces were further deposited with silver nanoparticles (Ag NPs) via in-situ reduction of Ag ions using catechol moieties as the reducing agents. The resulting AgNPs/CACS-coated Ti surfaces exhibit antibacterial properties and can prevent the surface adhesion of bacterial cells, as evidenced by the inhibition zone test, live/dead bacterial staining assay and spread plate method. In addition, they show negligible cytotoxicity to L929 mouse fibroblast cells.
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cheng2019deposition Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cheng, Yan Fang;Zhang, Jie Yu;Wang, Yun Bing;Li, Chang Ming;Lu, Zhi Song;Hu, Xue Feng;Xu, Li Qun;
Journal materials science & engineering c, materials for biological applications
Year 2019
DOI
S0928-4931(18)31624-2
URL
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