Effects of Arginine and Its Deprivation on Human Glioblastoma Physiology and Signaling.

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ID: 93067
2020
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Abstract
The observations that numerous cancers are characterized by impairment in arginine synthesis and that deficit of exogenous arginine specifically affects their growth and viability are the ground for arginine deprivation-based anticancer treatment strategy. This review addresses molecular mechanisms of the human glioblastoma cell response to arginine deprivation. Our earlier studies have shown that arginine deprivation specifically impairs glioblastoma cell motility, adhesion and invasiveness. These changes were evoked by alterations in the actin cytoskeleton organization resulting from a decreased arginylation of β-actin isoform. Moreover, deficit of arginine induces prolonged endoplasmic reticulum (ER) stress and activation of the unfolded protein response, not leading, however, to a massive apoptosis in glioblastoma cells. Our current research indicates that cell death could be augmented by other compounds such as modulators of ER stress, for example arginine analogue of plant origin, canavanine. Implication of these studies on the development of new anti-glioma metabolic therapeutic modalities are discussed.
Reference Key
karatsai2020effectsadvances Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Karatsai, Olena;Stasyk, Oleh;Redowicz, Maria Jolanta;
Journal advances in experimental medicine and biology
Year 2020
DOI
10.1007/978-3-030-30651-9_12
URL
Keywords
Migration glioblastoma arginine adhesion therapy actin cytoskeleton signaling invasiveness arginylation

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