Line Associated Thrombosis in Pediatric Patients With NF-κB Pathway Variants.

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ID: 93019
2020
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Abstract
Our report explores the complex role that nuclear factor-kappa B (NF-κB) plays in thrombosis formation, inflammation, and immunity; while additionally demonstrating that patients with NF-κB pathway pathogenic variants appear to carry a substantial thrombotic risk, particularly when secondary thrombotic risk factors are present. We propose that prophylactic anticoagulation should be strongly considered in such patients during high-risk situations and provide additional hematologic management strategies for those with NF-κB pathway alterations. We hope our work also calls to attention the potential need for a broader assessment of venous thromboembolism risk in patients with immune dysregulation to better delineate which patient populations may benefit from anticoagulation prophylaxis.
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michniacki2020linejournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michniacki, Thomas F;Atchison, Christie;Walkovich, Kelly;Sankar, Amanda;McGrath, Mary;Weyand, Angela C;
Journal journal of pediatric hematology/oncology
Year 2020
DOI
10.1097/MPH.0000000000001739
URL
Keywords
temperature antibiotics infections ttm antibiotic prophylaxis nosocomial infections

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