Line Associated Thrombosis in Pediatric Patients With NF-κB Pathway Variants.

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ID: 93019
2020
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Abstract
Our report explores the complex role that nuclear factor-kappa B (NF-κB) plays in thrombosis formation, inflammation, and immunity; while additionally demonstrating that patients with NF-κB pathway pathogenic variants appear to carry a substantial thrombotic risk, particularly when secondary thrombotic risk factors are present. We propose that prophylactic anticoagulation should be strongly considered in such patients during high-risk situations and provide additional hematologic management strategies for those with NF-κB pathway alterations. We hope our work also calls to attention the potential need for a broader assessment of venous thromboembolism risk in patients with immune dysregulation to better delineate which patient populations may benefit from anticoagulation prophylaxis.
Reference Key
michniacki2020linejournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Michniacki, Thomas F;Atchison, Christie;Walkovich, Kelly;Sankar, Amanda;McGrath, Mary;Weyand, Angela C;
Journal journal of pediatric hematology/oncology
Year 2020
DOI
10.1097/MPH.0000000000001739
URL
Keywords
temperature antibiotics infections ttm antibiotic prophylaxis nosocomial infections

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