Flavan derivative enantiomers and drimane sesquiterpene lactones from the Inonotus obliquus with neuroprotective effects.

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ID: 92717
2020
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Abstract
A pair of new flavan derivative enantiomers (1a and 1b), four new drimane sesquiterpene lactones (2-5) and a known compound (6) were isolated from Inonotus obliquus. Their structures were determined by comprehensive spectroscopic analyses. Compounds 1a/1b were separated by chiral chromatographic column successfully. The absolute configurations of compounds 1-5 were determined by comparison of their experimental and calculated ECD spectra. Notably, compounds 1a/1b represented the first pair of enantiomers in nature with tetrahydrofuran-flavan skeleton. A plausible biosynthetic pathway for (±)-1 was also proposed. All isolates were evaluated for their neuroprotective activities against HO-induced cell injury in SH-SY5Y cells. The results showed that compound 2 exhibited moderate neuroprotective activity at the concentration of 25.0 µM.
Reference Key
zou2020flavanbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zou, Chun-Xin;Wang, Xiao-Bo;Lv, Tian-Ming;Hou, Zi-Lin;Lin, Bin;Huang, Xiao-Xiao;Song, Shao-Jiang;
Journal Bioorganic chemistry
Year 2020
DOI
S0045-2068(19)32064-4
URL
Keywords
sh-sy5y cells drimane sesquiterpene flavan derivative inonotus obliquus neuroprotective activity

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