Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells

Ota, Yuki; Kawanai, Takuya; Watanabe, Ryo; Nishimura, Akira; Ago, Yukio; Takuma, Kazuhiro; Matsuda, Toshio

Effect of Overexpression of the Brain-Specific Na+/Ca2+ Exchanger Splice Variant NCX1.5 on NO Cytotoxicity in HEK293 Cells

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ID: 92551

2013

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Abstract.: Nitric oxide (NO) induces cytotoxicity in neuronal and glial cells via activation of the Na+/Ca2+ exchanger (NCX). This study examined the role of the predominant brain-specific NCX splice variant NCX1.5 in NO-induced cytotoxicity in the HEK293 cell expression system. Cells were transfected with the plasmid construct pcDNA3.1/V5-His containing full-length rat NCX1.5 cDNA. There was no difference in the cytotoxic effects of the NO donors sodium nitroprusside and S-nitroso-N-acetylpenicillamine between control and transfected cells. These results suggest that NO cytotoxicity is not dependent on NCX1.5. Keywords:: Na+/Ca2+ exchanger, nitric oxide, cytotoxicity

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Reference Key	ota2013effectjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors	Yuki Ota, Takuya Kawanai, Ryo Watanabe, Akira Nishimura, Yukio Ago, Kazuhiro Takuma, Toshio Matsuda Are you one of these authors? Claim your profile
Journal	Journal of pharmacological sciences
Year	2013
DOI	DOI not found Searching for DOI...
URL	http://www.sciencedirect.com/science/article/pii/S1347861319303664
Keywords	Therapeutics. Pharmacology environmental engineering earthwork. foundations

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Yuki Ota

Takuya Kawanai

Ryo Watanabe

Akira Nishimura

Yukio Ago

Kazuhiro Takuma

Toshio Matsuda

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