Microfluidic-Based Mechanical Phenotyping of Androgen-Sensitive and Non-sensitive Prostate Cancer Cells Lines.

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ID: 92262
2019
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Abstract
Cell mechanical properties have been identified to characterize cells pathologic states. Here, we report our work on high-throughput mechanical phenotyping of androgen-sensitive and non-sensitive human prostate cancer cell lines based on a morphological rheological microfluidic method. The theory for extracting cells' elastic modulus from their deformation and area, and the used experimental parameters were analyzed. The mechanical properties of three types of prostate cancer cells lines with different sensitivity to androgen including LNCaP, DU145, and PC3 were quantified. The result shows that LNCaP cell was the softest, DU145 was the second softest, and PC3 was the stiffest. Furthermore, atomic force microscopy (AFM) was used to verify the effectiveness of this high-throughput morphological rheological method.
Reference Key
liu2019microfluidicbasedmicromachines Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liu, Na;Du, Panpan;Xiao, Xiaoxiao;Liu, Yuanyuan;Peng, Yan;Yang, Chen;Yue, Tao;
Journal micromachines
Year 2019
DOI
E602
URL
Keywords
high-throughput cell deformability cellular mechanics microfluidic morphological rheology single-cell analysis

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