Multi-channel microfluidic chip coupling with mass spectrometry for simultaneous electro-sprays and extraction.

Clicks: 242
ID: 92245
2017
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Popular

Ranked #889 of 1,628 articles by views in Scientific reports

Most read Least read

Bar heights use a square-root scale. Only the 120 most-read articles are drawn; the journal has 1,628 in total.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Considering the advantages and research status of microfluidic chip coupling with mass spectrometry (MS), a microfluidic chip-based multi-channel ionization (MCMCI) for the extraction of untreated compounds in complex matrices without sample pretreatments was developed. Quantitative analysis of human urine spiked with various rhodamine B concentrations was also performed, and good linearity was obtained. Comparing to the macro ionization device, MCMCI significantly improved the integration of ionization source, simplified the operation of such a device, and greatly increased the signal intensity with much lower gas pressure. Comparison of our MCMCI with two and three gas channels indicated that the liquid-liquid extraction process before spraying and after spraying produced similar MS results. Moreover, this MCMCI with three gas channels also implemented simultaneous dual sprays with high DC voltages, the interference of two samples was minor and ion suppression effect was drastically alleviated. Such advantages may easily enable internal calibration for accurate mass measurement. Furthermore, dual extraction can be implemented by integrating such multi-spray configuration, which can improve the extracted signal intensity and sensitivity. These technologies open up new avenues for the application of microfluidic chip coupling with MS.
Reference Key
yu2017multichannelscientific Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yu, Cilong;Tang, Fei;Qian, Xiang;Chen, Yan;Yu, Quan;Ni, Kai;Wang, Xiaohao;
Journal Scientific reports
Year 2017
DOI
10.1038/s41598-017-17764-6
URL
Keywords
confocal microscopy fast imaging height measurements surface measurement three-dimensional microscopy

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.