IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials.

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ID: 92054
2019
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Abstract
Large B-cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.
Reference Key
chisholm2019irf4pediatric Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chisholm, Karen M;Mohlman, Jeffrey;Liew, Michael;Termuhlen, Amanda;Cairo, Mitchell S;Gross, Thomas G;Perkins, Sherrie L;Miles, Rodney R;
Journal pediatric blood & cancer
Year 2019
DOI
10.1002/pbc.27770
URL
Keywords
pediatric lymphoma diffuse large b-cell lymphoma follicular lymphoma, irf4

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