IRF4 translocation status in pediatric follicular and diffuse large B-cell lymphoma patients enrolled in Children's Oncology Group trials.

纳入儿童肿瘤协作组临床试验的儿童滤泡性及弥漫大B细胞淋巴瘤患者的IRF4易位状态。

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2019
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Abstract
Large B-cell lymphoma with IRF4 rearrangement is a provisional entity in the 2017 World Health Organization classification. In order to characterize these lymphomas in children from the United States, IRF4 FISH and immunohistochemical stains were performed on 32 follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) from Children's Oncology Group studies. Two DLBCLs (6%) had IRF4 rearrangements, one involving the ileocecal valve and another involving the tonsil and cerebrospinal fluid. Both cases had strong, diffuse IRF4/MUM1 immunohistochemical staining, which may be a pathologic clue to the diagnosis. Reclassification of these cases may have prognostic and therapeutic implications.
伴IRF4重排的大B细胞淋巴瘤是2017年世界卫生组织分类中的一种暂定实体。为明确该类淋巴瘤在美国儿童中的特征，研究对来自儿童肿瘤学组（Children's Oncology Group）研究的32例滤泡性淋巴瘤和弥漫性大B细胞淋巴瘤（DLBCL）进行了IRF4 FISH和免疫组织化学染色。其中2例DLBCL（6%）存在IRF4重排，1例累及回盲瓣，另1例累及扁桃体和脑脊液。两例标本的IRF4/MUM1免疫组化染色均呈弥漫强阳性，这可作为病理诊断的线索。对这些病例进行重新分类可能具有预后和治疗意义。
Reference Key
chisholm2019irf4pediatric Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Chisholm, Karen M;Mohlman, Jeffrey;Liew, Michael;Termuhlen, Amanda;Cairo, Mitchell S;Gross, Thomas G;Perkins, Sherrie L;Miles, Rodney R;
Journal pediatric blood & cancer
Year 2019
DOI
10.1002/pbc.27770
URL
Keywords
pediatric lymphoma diffuse large b-cell lymphoma follicular lymphoma, irf4

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