A Comparative Assessment of Nanotoxicity Induced by Metal (Silver, Nickel) and Metal Oxide (Cobalt, Chromium) Nanoparticles in .

Metal (Gümüş, Nikel) ve Metal Oksit (Kobalt, Krom) Nanoparçacıklarının İndüklediği Nanotoksisitenin Karşılaştırmalı Bir Değerlendirmesi.

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2019
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Abstract
In the present in vivo study, we provide a comparison of toxicological consequences induced by four different types of spherical nanoparticles (NPs)-silver nanoparticles (AgNPs, 40 ± 6 nm), nickel (NiNPs, 43 ± 6 nm), cobalt oxide (Co₃O₄NPs, 60 ± 6 nm), and chromium oxide (Cr₃O₄NPs, 50 ± 5 nm)-on freshwater fish . Fish were exposed to NPs (25 mg/L) for 21 days. We observed a NPs type-dependent toxicity in fish. An altered behavior showing signs of stress and a substantial reduction in total leukocyte count was noticed in all NP-treated groups. A low total erythrocyte count in all NP-treated fish except for Co₃O₄NPs was discerned while a low survival rate in the case of Cr₃O₄NP-treated fish was observed. A significant decrease in growth and hemoglobin were noticed in NiNP- and Cr₃O₄NP-treated fish. A considerable total protein elevation was detected in NiNP-, Co₃O₄NP-, and Cr₃O₄NP-treated groups. An upgrading in albumin level was witnessed in Co₃O₄NP- and Cr₃O₄NP-treated groups while a high level of globulin was noted in NiNP- and Co₃O₄NP-exposed groups. In all NP-treated groups, a depleted activity of antioxidative enzymes and pathological lesions in liver and kidney were noticed.
Bu *in vivo* çalışmada, dört farklı küresel nanopartikül (NP) türünün —gümüş nanopartiküller (AgNP'ler, 40 ± 6 nm), nikel (NiNP'ler, 43 ± 6 nm), kobalt oksit (Co₃O₄NP'ler, 60 ± 6 nm) ve krom oksit (Cr₃O₄NP'ler, 50 ± 5 nm)— tatlı su balıkları üzerinde indüklediği toksikolojik sonuçların bir karşılaştırması sunulmaktadır. Balıklar 21 gün boyunca NP'lere (25 mg/L) maruz bırakılmıştır. Balıklarda NP türüne bağlı bir toksisite gözlemlenmiştir. Tüm NP uygulanan gruplarda stres belirtileri gösteren davranış değişiklikleri ve toplam lökosit sayısında belirgin bir azalma tespit edilmiştir. Co₃O₄NP'ler haricindeki tüm NP uygulanan balıklarda düşük toplam eritrosit sayısı saptanırken, Cr₃O₄NP uygulanan balıklarda ise düşük bir hayatta kalma oranı gözlenmiştir. NiNP ve Cr₃O₄NP uygulanan balıklarda büyüme ve hemoglobin düzeylerinde anlamlı bir düşüş kaydedilmiştir. NiNP, Co₃O₄NP ve Cr₃O₄NP uygulanan gruplarda toplam proteinde kayda değer bir artış tespit edilmiştir. Co₃O₄NP ve Cr₃O₄NP uygulanan gruplarda albümin seviyesinde bir yükselme görülürken, NiNP ve Co₃O₄NP'ye maruz kalan gruplarda yüksek globülin seviyesi kaydedilmiştir. Tüm NP uygulanan gruplarda antioksidan enzim aktivitelerinde azalma ile karaciğer ve böbrekte patolojik lezyonlar gözlenmiştir.
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Authors Kanwal, Zakia;Raza, Muhammad Akram;Manzoor, Farkhanda;Riaz, Saira;Jabeen, Ghazala;Fatima, Shafaq;Naseem, Shahzad;
Journal Nanomaterials
Year 2019
DOI
E309
URL
Keywords
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