Narrative impairment, white matter damage and CSF biomarkers in the Alzheimer's disease spectrum.

Clicks: 397
ID: 91833
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #11 of 29 articles by views in Aging

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Narrative discourse (ND) refers to one's ability to verbally reproduce a sequence of temporally and logically-linked events. Impairments in ND may occur in subjects with Amnestic Mild Cognitive Impairment (aMCI) and Alzheimer's Disease (AD), but correlates across this function, neuroimaging and cerebrospinal fluid (CSF) AD biomarkers remain understudied.We sought to measure correlates among ND, Diffusion Tensor Imaging (DTI) indexes and AD CSF biomarkers in patients within the AD spectrum.Groups differed in narrative production (NProd) and comprehension. aMCI and AD presented poorer inference abilities than controls. AD subjects were more impaired than controls and aMCI regarding WB (p<0.01). ROIs DTI assessment distinguished the three groups. Mean Diffusivity (MD) in the uncinate, bilateral parahippocampal cingulate and left inferior occipitofrontal fasciculi negatively correlated with NProd. Changes in specific tracts correlated with T-tau/Aβ1-42 ratio in CSF.AD and aMCI patients presented more ND impairments than controls. Those findings were associated with changes in ventral language-associated and in the inferior parahippocampal pathways. The latest were correlated with biomarkers' levels in the CSF.AD (N=14), aMCI (N=31) and Control (N=39) groups were compared for whole brain (WB) and regions of interest (ROI) DTI parameters, ND and AD CSF biomarkers.
Reference Key
drummond2019narrativeaging Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Drummond, Claudia;Coutinho, Gabriel;Monteiro, Marina Carneiro;Assuncao, Naima;Teldeschi, Alina;de Souza, Andrea Silveira;Oliveira, Natalia;Bramati, Ivanei;Sudo, Felipe Kenji;Vanderboght, Bart;Brandao, Carlos Otavio;Fonseca, Rochele Paz;de Oliveira-Souza, Ricardo;Moll, Jorge;Mattos, Paulo;Tovar-Moll, Fernanda;
Journal Aging
Year 2019
DOI
10.18632/aging.102391
URL
Keywords
mild cognitive impairment white matter language alzheimer’s disease csf biomarkers

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.