Alpha-thalassemia among tribal populations of Eastern India.

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ID: 91341
2005
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Abstract
Five hundred and thirteen unrelated subjects belonging to various tribes of West Bengal, Arunachal Pradesh and Assam in Eastern India, were screened for the presence of alpha-thalassemia (thal) gene deletion(s) as a possible cause of unexplained anemia (Hb < 11 g/dL and/or MCH <28 pg, MCV < 78 fL). As reported earlier, beta-globin gene mutant alleles were found with a frequency of up to 20% in some tribes. In the present study, alpha-globin gene deletion alleles were found in 18% of subjects from West Bengal, 3.9% from Arunachal Pradesh and 3.84% from Assam tribesmen. Coexistence of alpha- and beta-globin gene abnormalities was observed in up to 18% of some tribal groups. The high inbreeding rate and lack of appropriate medical care make these populations particularly vulnerable.
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Authors Sen, Rinini;Chakrabarti, Sila;Sengupta, Bani;De, Madhusnata;Haldar, Ajanta;Poddar, Sandeep;Gajra, Bani;Talukder, Geeta;Sengupta, Sarthak;
Journal hemoglobin
Year 2005
DOI
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Keywords
india tuberculosis indigenous population tribal disadvantaged population

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