The molecular patterns of resistance to anti-tuberculosis drugs: an analysis from Istanbul, Turkey.

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2020
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Abstract
Resistances to anti-tuberculosis (TB) drugs are related to the mutations in the genome of the complex (MTBC). To expose the genomic mutations that cause anti-TB drug resistance. The GenoType MTBDRplus and MTBDRsl assays were used to detect genetic mutations. In this study of 1329 MTBC isolates, the sensitivities and specificities of genotypic methods for the detection of isoniazid (INH), rifampicin (RIF), ethambutol (EMB), and multi-drug resistance were 0.77, 0.84, 0.65, 0.89 and 0.99, 0.98, 0.67, 0.94, respectively. MUT3 mutations (S531L) of the gene for RIF resistance and MUT1 mutations (S315T1 and C15T) of the and genes for INH resistance were dominant. The most frequently observed mutations that created resistance to fluoroquinolones (FLQ) were MUT3C (D94G) of the gene. The predominant mutations of EMB resistance were MUT1B (M306V) of the gene. Aminoglycosides/cyclic peptides (AG/CP) resistance was rare. The molecular mechanisms of anti-TB drugs resistance in MTBC strains found in Istanbul are similar to those in the literature.
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yazisiz2020thejournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Yazisiz, Hatice;Hircin Cenger, Derya;Uçarman, Nilay;Altin, Sedat;
Journal journal of chemotherapy (florence, italy)
Year 2020
DOI
10.1080/1120009X.2020.1716477
URL
Keywords
Drug resistance Mycobacterium tuberculosis mdr-tb xdr-tb genotype mtbdrplus genotype mtbdrsl

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