Smartphone epifluorescence microscopy for cellular imaging of fresh tissue in low-resource settings.

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ID: 91033
2020
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Ranked #2 of 18 articles by views in Biomedical optics express

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Abstract
Disease diagnosis in low-resource settings can be challenging due to the lack of equipment and trained personnel required for histologic analysis. In this paper, we have developed a smartphone-based epifluorescence microscope (SeFM) for imaging fresh tissues at sub-cellular resolution. SeFM provides similar resolution and field of view (FOV) as those used during histologic analysis. The SeFM device achieved the lateral resolution of 0.57 µm and provided microscopy images over a sample area larger than 500 µm. The material cost was low, approximately $3,000. Preliminary images of human pancreatic tumor specimens clearly visualized cellular details. Quantitative analysis showed that using an excess dose of a chemotherapy drug significantly reduced the tumor-specific fluorescence signal, confirming the specificity of the drug and the detection potential of SeFM.
Reference Key
zhu2020smartphonebiomedical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhu, Wenbin;Pirovano, Giacomo;O'Neal, Patrick K;Gong, Cheng;Kulkarni, Nachiket;Nguyen, Christopher D;Brand, Christian;Reiner, Thomas;Kang, Dongkyun;
Journal Biomedical optics express
Year 2020
DOI
10.1364/BOE.11.000089
URL
Keywords
Atrial fibrillation telemedicine randomized controlled trial hospitalization heart failure integrated care care center disease management program evidence-based care treatment-resistant hypertension

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