Natural Aristolactams and Aporphine Alkaloids as Inhibitors of CDK1/Cyclin B and DYRK1A

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ID: 90195
2013
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Abstract
In an effort to find potent inhibitors of the protein kinases DYRK1A and CDK1/Cyclin B, a systematic in vitro evaluation of 2,500 plant extracts from New Caledonia and French Guyana was performed. Some extracts were found to strongly inhibit the activity of these kinases. Four aristolactams and one lignan were purified from the ethyl acetate extracts of Oxandra asbeckii and Goniothalamus dumontetii, and eleven aporphine alkaloids were isolated from the alkaloid extracts of Siparuna pachyantha, S. decipiens, S. guianensis and S. poeppigii. Among these compounds, velutinam, aristolactam AIIIA and medioresinol showed submicromolar IC50 values on DYRK1A.
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guritte2013naturalmolecules Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Guéritte, Françoise;Litaudon, Marc;Meijer, Laurent;Lozach, Olivier;Dumontet, Vincent;Amand, Séverine;Bodo, Bernard;Apel, Cécile;Ven, Jessica Le;Eparvier, Véronique;Morleo, Barbara;Marti, Guillaume;
Journal molecules
Year 2013
DOI
DOI not found
URL
http://www.mdpi.com/1420-3049/18/3/3018
Keywords
chemistry Organic Chemistry Science (General) Science

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