Aristolochic acid derivatives from the rhizome of Arisolochia championii.

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ID: 90166
2017
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Abstract
Four new aristolochic acid derivatives aristchamic A (1), aristchamic B (2), aristochamic C (3a), aristchamic D (3b) and one new aristolactam aristolactam-CV (4), together with 10 known compounds (5-14), were isolated from the rhizomes of Aristolochia championii. Their structures were assigned by detailed analysis of MS and NMR spectroscopic data. All of the isolated compounds were evaluated for their cytotoxic activities against HCT-116, HepG2, BGC-823, NCI-H1650, and A2780 cell. Compound 1 exhibited significant cytotoxic activity against HCT-116, HepG2, BGC-823, and NCI-H1650, with IC values of 0.50, 7.37, 2.66, and 0.75μM, respectively.
Reference Key
wang2017aristolochicfitoterapia Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wang, Xin;Shi, Guo-Ru;Liu, Yan-Fei;Li, Li;Chen, Ruo-Yun;Yu, De-Quan;
Journal Fitoterapia
Year 2017
DOI
S0367-326X(16)31022-X
URL
Keywords
cytotoxic activity aristolochic acid aristchamic a–d aristolochia aristolochia championii

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