Total synthesis of aristolactam alkaloids synergistic C-H bond activation and dehydro-Diels-Alder reactions.

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ID: 90164
2017
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Abstract
A concise total synthesis of aristolactam alkaloids by a synergistic combination of C-H bond activation and dehydro-Diels-Alder reactions is described. To achieve the synthesis two new synthetic methodologies, namely the oxidative cyclization of benzamides with vinyl sulfone leading to 3-methyleneisoindolin-1-ones a ruthenium-catalyzed C-H bond activation, and a dehydro-Diels-Alder reaction followed by the fluoride ion mediated desulfonylation of 3-methyleneisoindolin-1-ones with benzynes, were developed. The method presented allows the opportunity for the construction of all the rings of aristolactams from easily available starting materials.
Reference Key
reddy2017totalchemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Reddy, Mallu Chenna;Jeganmohan, Masilamani;
Journal Chemical science
Year 2017
DOI
10.1039/c7sc00161d
URL
Keywords
nephrotoxicity metabolomics lc-ms asarum aristolactam

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