Sulfur-Containing Aristoloxazines and Other Constituents of the Roots of Aristolochia orbicularis.

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ID: 90158
2017
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Abstract
Six new compounds, aristoloxazine A (1), aristoloxazine B (2), 7-methoxytaliscanine (3), humul-7-en-1,4,11-triol (4), 8-hydroxy-β-logipinene (5), and 1β-hydroxy-4(14)-eudesmene (6), corresponding to two sulfur-containing aristoloxazines (1 and 2), an aristolactam (3), and three sesquiterpenes (4-6) were isolated, along with 26 known compounds, from the roots of Aristolochia orbicularis. The structures of the new compounds were established based on their spectroscopic and spectrometric data and in the case of aristoloxazine A (1) by single-crystal X-ray crystallography. This is the first report of sulfur-containing aristoloxazines from a natural source. Furthermore, aristoloxazine A (1) was found to possess potent in vitro antimicrobial activity against all resistant Staphylococcus aureus and several fungal strains in which it was evaluated.
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Authors Rios, María Yolanda;Navarro, Víctor;Ramírez-Cisneros, M Ángeles;Salazar-Rios, Enrique;
Journal Journal of natural products
Year 2017
DOI
10.1021/acs.jnatprod.7b00226
URL
Keywords
high-performance liquid chromatography amides aristolactams matrix solid phase dispersion (mspd) saururus chinensis

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