Pd(II)/Cu(II)-Catalyzed Regio- and Stereoselective Synthesis of ( E)-3-Arylmethyleneisoindolin-1-ones Using Air as the Terminal Oxidant.

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2018
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Abstract
Regio- and stereoselective synthesis of ( E)-3-arylmethyleneisoindolin-1-ones via Pd(II)/Cu(II)-catalyzed one-pot C-C/C-N bond forming sequence between amides and styrenes is reported. This method provides facile and rapid access to a diverse range of such compounds using readily available starting materials under mild aerobic conditions with good functional group tolerance and high selectivity and efficiency. Further elaboration of the products obtained from this process enabled very short and efficient syntheses of aristolactam and indoloisoquinolinone alkaloids.
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youn2018pdiicuiicatalyzedorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Youn, So Won;Ko, Tae Yun;Kim, Young Ho;Kim, Yun Ah;
Journal Organic letters
Year 2018
DOI
10.1021/acs.orglett.8b03409
URL
Keywords
aristolochic acid upper tract urothelial carcinoma aristolochia species balkan endemic nephropathy aristolochic acid nephropathy

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