Genome-Scale Metabolic Reconstruction of 386B, a Candidate Functional Starter Culture for Cocoa Bean Fermentation.

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ID: 89769
2019
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Abstract
386B is a candidate functional starter culture for the cocoa bean fermentation process. To allow simulations of its related metabolism in response to different environmental conditions, a genome-scale metabolic model for 386B was reconstructed. This is the first genome-scale metabolic model reconstruction for a member of the genus . The metabolic network reconstruction process was based on extensive genome re-annotation and comparative genomics analyses. The information content related to the functional annotation of metabolic enzymes and transporters was placed in a metabolic context by exploring and curating a Pathway/Genome Database of 386B using the Pathway Tools software. Metabolic reactions and curated gene-protein-reaction associations were bundled into a genome-scale metabolic model of 386B, named iAp386B454, containing 454 genes, 322 reactions, and 296 metabolites embedded in two cellular compartments. The reconstructed model was validated by performing growth experiments in a defined medium, which revealed that lactic acid as the sole carbon source could sustain growth of this strain. Further, the reconstruction of the 386B genome-scale metabolic model revealed knowledge gaps concerning the metabolism of this strain, especially related to the biosynthesis of its cell envelope and the presence or absence of metabolite transporters.
Reference Key
pelicaen2019genomescalefrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Pelicaen, Rudy;Gonze, Didier;Teusink, Bas;De Vuyst, Luc;Weckx, Stefan;
Journal Frontiers in microbiology
Year 2019
DOI
10.3389/fmicb.2019.02801
URL
Keywords
genome annotation genome-scale metabolic model acetic acid bacteria acetobacter pasteurianus cocoa bean fermentation process

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