Polymer-fiber-coupled field-effect sensors for label-free deep brain recordings.

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ID: 89646
2020
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Abstract
Electrical recording permits direct readout of neural activity but offers limited ability to correlate it to the network topography. On the other hand, optical imaging reveals the architecture of neural circuits, but relies on bulky optics and fluorescent reporters whose signals are attenuated by the brain tissue. Here we introduce implantable devices to record brain activities based on the field effect, which can be further extended with capability of label-free electrophysiological mapping. Such devices reply on light-addressable potentiometric sensors (LAPS) coupled to polymer fibers with integrated electrodes and optical waveguide bundles. The LAPS utilizes the field effect to convert electrophysiological activity into regional carrier redistribution, and the neural activity is read out in a spatially resolved manner as a photocurrent induced by a modulated light beam. Spatially resolved photocurrent recordings were achieved by illuminating different pixels within the fiber bundles. These devices were applied to record local field potentials in the mouse hippocampus. In conjunction with the raster-scanning via the single modulated beam, this technology may enable fast label-free imaging of neural activity in deep brain regions.
Reference Key
guo2020polymerfibercoupledplos Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Guo, Yuanyuan;Werner, Carl F;Canales, Andres;Yu, Li;Jia, Xiaoting;Anikeeva, Polina;Yoshinobu, Tatsuo;
Journal PloS one
Year 2020
DOI
10.1371/journal.pone.0228076
URL
Keywords
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