Propagation-based phase-contrast tomography of a guinea pig inner ear with cochlear implant using a model-based iterative reconstruction algorithm.

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ID: 89295
2018
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Abstract
Propagation-based phase-contrast computed tomography has become a valuable tool for visualization of three-dimensional biological samples, due to its high contrast between materials with similar attenuation properties. However, one of the most-widely used phase-retrieval algorithms imposes a homogeneity assumption onto the sample, which leads to artifacts for numerous applications where this assumption is violated. Prominent examples are biological samples with highly-absorbing implants. Using synchrotron radiation, we demonstrate by the example of a guinea pig inner ear with a cochlear implant electrode, how a recently developed model-based iterative algorithm for propagation-based phase-contrast computed tomography yields distinct benefits for such a task. We find that the model-based approach improves the overall image quality, removes the detrimental influence of the implant and accurately visualizes the cochlea.
Reference Key
hehn2018propagationbasedbiomedical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hehn, Lorenz;Gradl, Regine;Voss, Andrej;Günther, Benedikt;Dierolf, Martin;Jud, Christoph;Willer, Konstantin;Allner, Sebastian;Hammel, Jörg U;Hessler, Roland;Morgan, Kaye S;Herzen, Julia;Hemmert, Werner;Pfeiffer, Franz;
Journal Biomedical optics express
Year 2018
DOI
10.1364/BOE.9.005330
URL
Keywords
(100.5070) phase retrieval (170.6960) tomography

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