Vienna LiverTox Workspace-A Set of Machine Learning Models for Prediction of Interactions Profiles of Small Molecules With Transporters Relevant for Regulatory Agencies.

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ID: 88264
2019
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Abstract
Transporters expressed in the liver play a major role in drug pharmacokinetics and are a key component of the physiological bile flow. Inhibition of these transporters may lead to drug-drug interactions or even drug-induced liver injury. Therefore, predicting the interaction profile of small molecules with transporters expressed in the liver may help medicinal chemists and toxicologists to prioritize compounds in an early phase of the drug development process. Based on a comprehensive analysis of the data available in the public domain, we developed a set of classification models which allow to predict-for a small molecule-the inhibition of and transport by a set of liver transporters considered to be relevant by FDA, EMA, and the Japanese regulatory agency. The models were validated by cross-validation and external test sets and comprise cross validated balanced accuracies in the range of 0.64-0.88. Finally, models were implemented as an easy to use web-service which is freely available at https://livertox.univie.ac.at.
Reference Key
montanari2019viennafrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Montanari, Floriane;Knasmüller, Bernhard;Kohlbacher, Stefan;Hillisch, Christoph;Baierová, Christine;Grandits, Melanie;Ecker, Gerhard F;
Journal Frontiers in chemistry
Year 2019
DOI
10.3389/fchem.2019.00899
URL
Keywords
toxicity Machine learning abc-transporter oatp-transporter vienna livertox workspace classification models web service

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