Expression of HSP70 and Its Relation with Other Cytokines in Human Middle Ear Effusion

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ID: 87813
2010
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Abstract
ObjectivesWhile other cytokines are known to be associated with otitis media with effusion (OME), the involvement of heat shock protein 70 (HSP70) in middle ear effusion (MEE) is unknown. This study was undertaken to investigate the possibility of there being a HSP70 expression in human MEE and to determine its potential role as a cytokine in OME.MethodsThe levels of HSP70, tumor necrosis factor-alpha and interleukin-1beta were measured by enzyme-linked immunosorbent assay in the effusion of different groups of OME patient following collection of the MEE using our new collection system. The clinical characteristics of the OME patients and the MEE status were analyzed.ResultsHSP70 was expressed in all the types of MEE. The mucous and seromucous effusions showed higher HSP70 levels than that of the serous effusion. The HSP70 level was correlated with the levels of tumor necrosis factor (TNF)-α and interleukin (IL)-1β in the effusions. The positive correlations between HSP70, TNF-α and IL-1β were statistically significant (P<0.05).ConclusionThe highly elevated level of HSP70 in the seromucous and mucous effusions implicates this protein in the chronicity of OME.
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Authors Park, Shi-Nae;Park, Kyoung Ho;Choi, Hyeog-Gi;Shin, Ji Hyun;Lee, Dong Hee;Chang, Ki Hong;Yeo, Sang Won;
Journal clinical and experimental otorhinolaryngology
Year 2010
DOI
DOI not found
URL
http://www.e-ceo.org/upload/pdf/ceo-3-18.pdf
Keywords
chemistry Biology (General) Medicine Science (General) Science otorhinolaryngology neurosciences. biological psychiatry. neuropsychiatry gynecology and obstetrics social sciences (general) animal culture diseases of the genitourinary system. urology reproduction

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