The Host Heat Shock Protein MRJ/DNAJB6 Modulates Virus Infection.

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ID: 87762
2019
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Ranked #103 of 201 articles by views in Frontiers in microbiology

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Abstract
A variety of pathogens take advantage of cellular heat shock proteins (HSPs) to complete their life cycle and exert pathogenic effects. MRJ (DNAJB6), a member of the heat shock protein 40 family, acts as a molecular chaperone for a wide range of cellular processes. MRJ mutations are linked to human diseases, such as muscular dystrophy and neurodegenerative diseases. There are two MRJ isoforms generated by alternative use of terminal exons, which differ in their C-terminus. This mini-review summarizes how these two MRJ isoforms participate differentially in viral production and virulence, and the possibility for MRJ as a therapeutic target.
Reference Key
ko2019thefrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ko, Shih-Han;Huang, Li-Min;Tarn, Woan-Yuh;
Journal Frontiers in microbiology
Year 2019
DOI
10.3389/fmicb.2019.02885
URL
Keywords
virus heat shock protein hsp40 mrj morpholino oligonucleotide

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