Roles of Rap1 signaling in tumor cell migration and invasion

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ID: 87564
2017
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Abstract
Ras-associated protein-1 (Rap1), a small GTPase in the Ras-related protein family, is an important regulator of basic cellular functions (e.g., formation and control of cell adhesions and junctions), cellular migration, and polarization. Through its interaction with other proteins, Rap1 plays many roles during cell invasion and metastasis in different cancers. The basic function of Rap1 is straightforward; it acts as a switch during cellular signaling transduction and regulated by its binding to either guanosine triphosphate (GTP) or guanosine diphosphate (GDP). However, its remarkably diverse function is rendered by its interplay with a large number of distinct Rap guanine nucleotide exchange factors and Rap GTPase activating proteins. This review summarizes the mechanisms by which Rap1 signaling can regulate cell invasion and metastasis, focusing on its roles in integrin and cadherin regulation, Rho GTPase control, and matrix metalloproteinase expression.
Reference Key
zhang2017rolescancer Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Yi-Lei;Wang, Ruo-Chen;Cheng, Ken;Ring, Brian Z.;Su, Li;
Journal cancer biology & medicine
Year 2017
DOI
DOI not found
URL
http://www.cancerbiomed.org/index.php/cocr/article/view/1012
Keywords
Pharmacy and materia medica Therapeutics. Pharmacology environmental sciences neoplasms. tumors. oncology. including cancer and carcinogens business energy industries. energy policy. fuel trade forestry

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