3M-Brazzein as a natural sugar substitute attenuates obesity, metabolic disorder, and inflammation.

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ID: 87396
2020
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Abstract
Obesity is a global chronic disease linked to various diseases. Increased consumption of added sugars, especially in beverages, is a key contributor to the obesity epidemic. It is essential to reduce or replace sugar intake with low-calorie sweeteners. Here, a natural sweet protein, 3M-brazzein, was investigated as a possible sugar substitute. Mice were exposed to 3M-brazzein or 10% sucrose of equivalent sweetness, in drinking water, to mimic human obesity development over 15 weeks. Consumption of 3M-brazzein in liquid form did not cause adiposity hypertrophy, resulting in 33.1 ± 0.4 g body weight and 0.90 ± 0.2 mm fat accumulation, which was 35.9 ± 0.7 g ; p = 0.0094, 1.53 ± 0.067 mm; p = 0.0031, respectively for sucrose supplement. Additionally, 3M-brazzein did not disrupt glucose homeostasis or affect insulin resistance and inflammation. Due to its naturally low-calorie content, 3M-brazzein could also be a potential sugar substitute that reduces adiposity.
Reference Key
kim20203mbrazzeinjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hansaem Kim, Jaeyong Kang, Seungwoo Hong, Seonyeong Jo, Hyangsoon Noh, Byung-Ha Kang, Suhyun Park, Young-Jin Seo, Kwang-Hoon Kong, Sungguan Hong
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Journal Journal of agricultural and food chemistry
Year 2020
DOI
10.1021/acs.jafc.0c00317
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Keywords
antioxidant rats ionizing radiation neurogenesis morris water maze

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