3M-Brazzein as a natural sugar substitute attenuates obesity, metabolic disorder, and inflammation.

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ID: 87396
2020
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Abstract
Obesity is a global chronic disease linked to various diseases. Increased consumption of added sugars, especially in beverages, is a key contributor to the obesity epidemic. It is essential to reduce or replace sugar intake with low-calorie sweeteners. Here, a natural sweet protein, 3M-brazzein, was investigated as a possible sugar substitute. Mice were exposed to 3M-brazzein or 10% sucrose of equivalent sweetness, in drinking water, to mimic human obesity development over 15 weeks. Consumption of 3M-brazzein in liquid form did not cause adiposity hypertrophy, resulting in 33.1 ± 0.4 g body weight and 0.90 ± 0.2 mm fat accumulation, which was 35.9 ± 0.7 g ; p = 0.0094, 1.53 ± 0.067 mm; p = 0.0031, respectively for sucrose supplement. Additionally, 3M-brazzein did not disrupt glucose homeostasis or affect insulin resistance and inflammation. Due to its naturally low-calorie content, 3M-brazzein could also be a potential sugar substitute that reduces adiposity.
Reference Key
kim20203mbrazzeinjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kim, Hansaem;Kang, Jaeyong;Hong, Seungwoo;Jo, Seonyeong;Noh, Hyangsoon;Kang, Byung-Ha;Park, Suhyun;Seo, Young-Jin;Kong, Kwang-Hoon;Hong, Sungguan;
Journal Journal of agricultural and food chemistry
Year 2020
DOI
10.1021/acs.jafc.0c00317
URL
Keywords
antioxidant rats ionizing radiation neurogenesis morris water maze

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