Design and synthesis of novel Imidazo[2,1-b]thiazole derivatives as potent antiviral and antimycobacterial agents.

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ID: 86348
2019
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Abstract
A series of novel acyl-hydrazone (4a-d) and spirothiazolidinone (5a-d, 6a-d) derivatives of imidazo[2,1-b]thiazole were synthesized and evaluated for their antiviral and antimycobacterial activity. The antituberculosis activity was evaluated by using the Microplate Alamar Blue Assay and the antiviral activity was evaluated against diverse viruses in mammalian cell cultures. According to the biological activity studies of the compounds, 5a-c displayed hope promising antitubercular activity, 6d was found as potent for Coxsackie B4 virus, 5d was found as effective against Feline corona and Feline herpes viruses. Consequently, the obtained results displayed that, 5a-d and 6d present a leading structure for future drug development due to its straightforward synthesis and relevant bioactivity.
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gursoy2019designbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gürsoy, Elif;Dincel, Efe Doğukan;Naesens, Lieve;Ulusoy Güzeldemirci, Nuray;
Journal Bioorganic chemistry
Year 2019
DOI
S0045-2068(19)30998-8
URL
Keywords
synthesis imidazo[2,1-b]thiazole biological activity ketone hydrazone spirothiazolidinone

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