Antifungal potential of marine natural products.

Clicks: 398
ID: 86302
2017
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Abstract
Fungal diseases represent an increasing threat to human health worldwide which in some cases might be associated with substantial morbidity and mortality. However, only few antifungal drugs are currently available for the treatment of life-threatening fungal infections. Furthermore, plant diseases caused by fungal pathogens represent a worldwide economic problem for the agriculture industry. The marine environment continues to provide structurally diverse and biologically active secondary metabolites, several of which have inspired the development of new classes of therapeutic agents. Among these secondary metabolites, several compounds with noteworthy antifungal activities have been isolated from marine microorganisms, invertebrates, and algae. During the last fifteen years, around 65% of marine natural products possessing antifungal activities have been isolated from sponges and bacteria. This review gives an overview of natural products from diverse marine organisms that have shown in vitro and/or in vivo potential as antifungal agents, with their mechanism of action whenever applicable. The natural products literature is covered from January 2000 until June 2015, and we are reporting the chemical structures together with their biological activities, as well as the isolation source.
Reference Key
elhossary2017antifungaleuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors El-Hossary, Ebaa M;Cheng, Cheng;Hamed, Mostafa M;El-Sayed Hamed, Ashraf Nageeb;Ohlsen, Knut;Hentschel, Ute;Abdelmohsen, Usama Ramadan;
Journal European journal of medicinal chemistry
Year 2017
DOI
S0223-5234(16)30960-6
URL
Keywords
Antifungal Activity secondary metabolites fungal infections marine invertebrates marine microorganisms marine natural products

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