Biomaterials and Magnetic Stem Cell Delivery in the Treatment of Spinal Cord Injury.

Clicks: 339
ID: 86245
2020
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Ranked #3 of 20 articles by views in Neurochemical research

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Abstract
Spinal cord injury (SCI) is a serious trauma, which often results in a permanent loss of motor and sensory functions, pain and spasticity. Despite extensive research, there is currently no available therapy that would restore the lost functions after SCI in human patients. Advanced treatments use regenerative medicine or its combination with various interdisciplinary approaches such as tissue engineering or biophysical methods. This review summarizes and critically discusses the research from specific interdisciplinary fields in SCI treatment such as the development of biomaterials as scaffolds for tissue repair, and using a magnetic field for targeted cell delivery. We compare the treatment effects of synthetic non-degradable methacrylate-based hydrogels and biodegradable biological scaffolds based on extracellular matrix. The systems using magnetic fields for magnetically guided delivery of stem cells loaded with magnetic nanoparticles into the lesion site are then suggested and discussed.
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kubinov2020biomaterialsneurochemical Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kubinová, Šárka;
Journal Neurochemical research
Year 2020
DOI
10.1007/s11064-019-02808-2
URL
Keywords
hydrogel biomaterials spinal cord injury magnetic field cell delivery

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