Magnetically Navigated Intracellular Delivery of Extracellular Vesicles Using Amphiphilic Nanogels.

Clicks: 419
ID: 86243
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #3 of 41 articles by views in bioconjugate chemistry

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Various cells in vivo secrete exosomes consisting of lipid bilayers. They carry mRNAs and miRNAs capable of controlling cellular functions and can be used as drug delivery system nanocarriers. There is the current need to further improve the efficiency of exosome uptake into target cells. In this study, we prepared a hybrid of exosomes and magnetic nanoparticles, which could be guided to target cells by a magnetic field for efficient uptake. Magnetic nanogels were prepared and hybridized to fluorescently labeled exosomes isolated from PC12 cells. By applying a magnetic field to a hybrid with magnetic nanogel, exosomes were efficiently transferred into target cells as confirmed by confocal laser microscopy. Finally, we found that differentiation of adipose-derived stem cells to neuron-like cells was enhanced by magnetic induction of the exosome-magnetic nanogel hybrid, indicating maintenance of the intrinsic functions of the exosomes in the differentiation of adipose-derived stem cells.
Reference Key
mizuta2019magneticallybioconjugate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mizuta, Ryosuke;Sasaki, Yoshihiro;Kawasaki, Riku;Katagiri, Kiyofumi;Sawada, Shin-Ichi;Mukai, Sada-Atsu;Akiyoshi, Kazunari;
Journal bioconjugate chemistry
Year 2019
DOI
10.1021/acs.bioconjchem.9b00369
URL
Keywords
macrophage magnetic field cell delivery colon delivery magnetic lipoplex plasmid dna

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.