Bioengineering strategies for nephrologists: kidney was not built in a day.

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ID: 86200
2020
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Abstract
: The number of patients with end-stage kidney disease is increasing worldwide, creating an unprecedented organ shortage. The kidney is a highly complex structure performing many crucial functions. Dialysis replaces filtration but not all other kidney functions and transplant is limited by kidney availability. Numerous innovative ways are being explored to obtain new kidneys for disease modeling and potentially replace lost kidney functions.: In this review, we will go through the different approaches that have been developed over the years to build kidneys. We will first present the current advances in xenotransplantation and generation of interspecies chimeras. Next, we will examine the attempts to create bioengineered kidneys with hemodialysis-derived implantable devices and decellularized organs. Finally, we will examine how organoids and microfluidic devices could answer important pathophysiological questions and model the path toward creating functional organs, for example through 3D bioprinting.: While all the aforementioned approaches to create new kidneys are promising, their translation into clinical practice seems a long way off, except xenotransplantation. Nonetheless, these novel technologies already consent disease modeling and drug testing at 3D level. We will review the stages of progress toward patient therapy and advantages/drawbacks of the various strategies.
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peired2020bioengineeringexpert Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Peired, Anna Julie;Mazzinghi, Benedetta;De Chiara, Letizia;Guzzi, Francesco;Lasagni, Laura;Romagnani, Paola;Lazzeri, Elena;
Journal expert opinion on biological therapy
Year 2020
DOI
10.1080/14712598.2020.1709439
URL
Keywords
scaffolds bioengineering organoids microfluidic device 3d bioprinting chimeric kidney portable bioartificial kidney xenotransplantation

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