Click Chemistry-Assisted Synthesis of a β-d-Galactose-Targeted SiO@RC Shell-Core Structure as a Nanoplatform for Metal-Based Complex Delivery.

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ID: 85863
2018
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Abstract
A facile reversed-phase microemulsion method was used to synthesize shell-core nanospheres of SiO@RCs (SiO-encapsuled rare-earth metal complexes). β-d-Galactose was then grafted onto the surfaces of the nanospheres through the copper(I)-catalyzed azide-alkyne cycloaddition click reaction for targeted delivery. The chemical characteristics and surface profiles of the nanocarriers were investigated by Fourier transform infrared spectroscopy, dynamic light scattering, transmission electron microscopy, and scanning electron microscopy. A high-efficiency microwave synthesis method was applied to prepare five complex cores by the reaction of different rare-earth metal salts with two isomeric ligands, o-CPA (2-chlorophenoxyacetic acid) and m-CPA (3-chlorophenoxyacetic acid). The crystal structures of the five synthesized RC cores were confirmed through X-ray diffraction, which revealed the formulas of five RCs, [Dy( o-CPA)(HO)]·HO RC, [Ho( o-CPA)(HO)]·HO RC, 2[Er( m-CPA)(HO)]·3HO RC, 2[Gd( m-CPA)(HO)]·3HO RC, and [Ce( m-CPA)(HO)]·2HO RC. An in vitro cell study revealed that all RCs exhibited certain anticancer activities. RC, in particular, showed the strongest cytotoxicity against HepG2 cells. The enhanced cell permeability and drug retention considerably improved the cytotoxicity of all SiO@RC-gal relative to that of RC. The selective uptake of the β-d-galactose-conjugated nanospheres by HepG2 cells through mechanisms mediated by cell surface receptors resulted in fewer side effects on extrahepatic tissues. Our contribution provides a novel design concept of a target SiO@RCs-gal nanocarrier for delivering affordable antitumor complexes in cancer therapy.
Reference Key
xu2018clickinorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Xu, Xiuling;Hu, Fan;Shuai, Qi;
Journal Inorganic chemistry
Year 2018
DOI
10.1021/acs.inorgchem.8b01335
URL
Keywords
lv@msn–cooh/gc msn–cooh sw620 cells calcium leucovorin galactosylated chitosan (gc) galectin receptor

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