Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases.

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ID: 85838
2020
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Abstract
Inflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently, there is a resurgence in the use of drugs from natural sources for various ailments as potent therapeutics. Berberine, an alkaloid prominent in the Chinese traditional system of medicine has been reported to exert therapeutic properties in various diseases. Nevertheless, the number of studies focusing on the curative potential of berberine in inflammatory diseases involving the respiratory system is limited. In this review, we have attempted to discuss the reported anti-inflammatory properties of berberine that function through several pathways such as, the NF-κB, ERK1/2 and p38 MAPK pathways which affect several pro-inflammatory cytokines in the pathophysiological processes involved in chronic respiratory diseases. This review would serve to provide valuable information to researchers who work in this field and a new direction in the field of drug discovery with respect to respiratory diseases.
Reference Key
tew2020immunologicalchemicobiological Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Tew, Xin Nee;Xin Lau, Natalie Jia;Chellappan, Dinesh Kumar;Madheswaran, Thiagarajan;Zeeshan, Farrukh;Tambuwala, Murtaza M;Aljabali, Alaa Aa;Balusamy, Sri Renukadevi;Perumalsamy, Haribalan;Gupta, Gaurav;Oliver, Brian G;Hsu, Alan;Wark, Peter;Reddy, Karosham;Wadhwa, Ridhima;Hansbro, Philip Michael;Dua, Kamal;
Journal Chemico-biological interactions
Year 2020
DOI
S0009-2797(19)31858-7
URL
Keywords
lung cancer asthma copd pulmonary fibrosis berberine respiratory diseases inflammatory diseases

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