Antitumor activity of an alkylating derivative of dipyridamole.

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Abstract
Synthesis of 2,6-Bis[bis(2-chloroethyl)amino]-4,8-dipiperidino-pyrimido [5,4-d]pyrimidine (DIP-C1) was carried out, and the new derivative showed cytotoxic activity comparable to other alkylating drugs on cultured P388 leukaemia cells and HeLa cells. The present paper reports the effects of DIP-C1 on respiration of Ehrlich ascites tumor cells and on survival of the mice implanted with Ehrlich ascites tumor cells. The compound showed a significant activity in both experimental models.
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Authors Andreani, A;Bossa, R;Fraccari, A;Galatulas, I;Ninci, M A;Rambaldi, M;
Journal Anticancer research
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