Age-related changes in eye lens biomechanics, morphology, refractive index and transparency.

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ID: 85688
2019
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Abstract
Life-long eye lens function requires an appropriate gradient refractive index, biomechanical integrity and transparency. We conducted an extensive study of wild-type mouse lenses 1-30 months of age to define common age-related changes. Biomechanical testing and morphometrics revealed an increase in lens volume and stiffness with age. Lens capsule thickness and peripheral fiber cell widths increased between 2 to 4 months of age but not further, and thus, cannot account for significant age-dependent increases in lens stiffness after 4 months. In lenses from mice older than 12 months, we routinely observed cataracts due to changes in cell structure, with anterior cataracts due to incomplete suture closure and a cortical ring cataract corresponding to a zone of compaction in cortical lens fiber cells. Refractive index measurements showed a rapid growth in peak refractive index between 1 to 6 months of age, and the area of highest refractive index is correlated with increases in lens nucleus size with age. These data provide a comprehensive overview of age-related changes in murine lenses, including lens size, stiffness, nuclear fraction, refractive index, transparency, capsule thickness and cell structure. Our results suggest similarities between murine and primate lenses and provide a baseline for future lens aging studies.
Reference Key
cheng2019agerelatedaging Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Cheng, Catherine;Parreno, Justin;Nowak, Roberta B;Biswas, Sondip K;Wang, Kehao;Hoshino, Masato;Uesugi, Kentaro;Yagi, Naoto;Moncaster, Juliet A;Lo, Woo-Kuen;Pierscionek, Barbara;Fowler, Velia M;
Journal Aging
Year 2019
DOI
10.18632/aging.102584
URL
Keywords
strain stiffness cataract epithelial cell fiber cell

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