Meta-regulation of Arabidopsis auxin responses depends on tRNA maturation.

Clicks: 238
ID: 85014
2015
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Abstract
Polar transport of the phytohormone auxin throughout plants shapes morphogenesis and is subject to stringent and specific control. Here, we identify basic cellular activities connected to translational control of gene expression as sufficient to specify auxin-mediated development. Mutants in subunits of Arabidopsis Elongator, a protein complex modulating translational efficiency via maturation of tRNAs, exhibit defects in auxin-controlled developmental processes, associated with reduced abundance of PIN-formed (PIN) auxin transport proteins. Similar anomalies are observed upon interference with tRNA splicing by downregulation of RNA ligase (AtRNL), pointing to a general role of tRNA maturation in auxin signaling. Elongator Protein 6 (ELP6) and AtRNL expression patterns underline an involvement in adjusting PIN protein levels, whereas rescue of mutant defects by auxin indicates rate-limiting activities in auxin-controlled organogenesis. This emphasizes mechanisms in which auxin serves as a bottleneck for plant morphogenesis, translating common cellular activities into defined developmental readouts.
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leitner2015metaregulationcell Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Johannes Leitner, Katarzyna Retzer, Nenad Malenica, Rasa Bartkeviciute, Doris Lucyshyn, Gunilla Jäger, Barbara Korbei, Anders Byström, Christian Luschnig
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Journal Cell reports
Year 2015
DOI
10.1016/j.celrep.2015.03.054
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