Between an ugly truth and a perfect lie: Wiping off fearful memories using beta-adrenergic receptors antagonists.

Clicks: 287
ID: 84973
2019
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Abstract
Psychiatric disorders such as anxiety, phobias, and post-traumatic stress disorder are considered of high global prevalence. Currently, a therapeutic approach to treat these disorders using beta-blockers, which antagonize the beta-adrenergic receptors (B1, B2, and B3) is being studied. This approach claims that beta-blockers, such as propranolol, inhibit fear memory reconsolidation. However, there are several studies refuting such claims by discrediting their experimental design and pointing out both the drugs pharmacokinetic properties and confounding factors. In this review, we explore the different effects of central beta-adrenergic agonists and antagonists on the fear memory consolidation providing mixed-evidence, limitations, and future directions.
Reference Key
alokda2019betweenjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors AlOkda, Abdelrahman M;Nasr, Mostafa M;Amin, Shaimaa N;
Journal journal of cellular physiology
Year 2019
DOI
10.1002/jcp.27441
URL
Keywords
beta blockers fear memories reconsolidation

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