Bottom-up engineering of cell-laden hydrogel microfibrous patch for guided tissue regeneration.

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ID: 84344
2020
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Ranked #40 of 133 articles by views in materials science & engineering c, materials for biological applications

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Abstract
The development of three-dimensional (3D) fibrous networks as platforms for tissue engineering applications has been attracting considerable attention. Opportunely arranged microscaled fibers offer an appealing biomimetic 3D architecture, with an open porous structure and a high surface-to-volume ratio. The present work describes the development of modified-alginate hydrogel microfibers for cell entrapment, using a purpose-designed flow circuit. For microfibers biofabrication, cells were suspended in gel-precursor alginate solution and injected in a closed-loop circuit with circulating cross-linking solution. The flow promoted stretching and solidification of continuous cell-loaded micro-scaled fibers that were collected in a strainer, assembling into a microfibrous patch. The process was optimized to allow obtaining a self-standing cohesive structure. After characterization of the microfibrous patch, the behavior of embedded human mesenchymal stem cells (hMSCs) was evaluated. Microfibers of oxidized alginate modified with integrin-binding ligands provided a suitable 3D cellular microenvironment, supporting hMSCs survival and stimulating the production of endogenous extracellular matrix proteins, such as fibronectin and collagen Type I. Collectively, these features make the proposed microfibrous structures stand out as promising 3D scaffolds for regenerative medicine.
Reference Key
campiglio2020bottomupmaterials Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Campiglio, Chiara Emma;Bidarra, Silvia J;Draghi, Lorenza;Barrias, Cristina C;
Journal materials science & engineering c, materials for biological applications
Year 2020
DOI
S0928-4931(19)32770-5
URL
Keywords
tissue engineering alginate cell entrapment cell-matrix interactions hydrogel microfibers

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