A genome-wide association study identifies genetic loci associated with specific lobar brain volumes.

Clicks: 308
ID: 84185
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #34 of 69 articles by views in Communications biology

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Brain lobar volumes are heritable but genetic studies are limited. We performed genome-wide association studies of frontal, occipital, parietal and temporal lobe volumes in 16,016 individuals, and replicated our findings in 8,789 individuals. We identified six genetic loci associated with specific lobar volumes independent of intracranial volume. Two loci, associated with occipital (6q22.32) and temporal lobe volume (12q14.3), were previously reported to associate with intracranial and hippocampal volume, respectively. We identified four loci previously unknown to affect brain volumes: 3q24 for parietal lobe volume, and 1q22, 4p16.3 and 14q23.1 for occipital lobe volume. The associated variants were located in regions enriched for histone modifications (DAAM1 and THBS3), or close to genes causing Mendelian brain-related diseases (ZIC4 and FGFRL1). No genetic overlap between lobar volumes and neurological or psychiatric diseases was observed. Our findings reveal part of the complex genetics underlying brain development and suggest a role for regulatory regions in determining brain volumes.
Reference Key
van-der-lee2019acommunications Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors van der Lee, Sven J;Knol, Maria J;Chauhan, Ganesh;Satizabal, Claudia L;Smith, Albert Vernon;Hofer, Edith;Bis, Joshua C;Hibar, Derrek P;Hilal, Saima;van den Akker, Erik B;Arfanakis, Konstantinos;Bernard, Manon;Yanek, Lisa R;Amin, Najaf;Crivello, Fabrice;Cheung, Josh W;Harris, Tamara B;Saba, Yasaman;Lopez, Oscar L;Li, Shuo;van der Grond, Jeroen;Yu, Lei;Paus, Tomas;Roshchupkin, Gennady V;Amouyel, Philippe;Jahanshad, Neda;Taylor, Kent D;Yang, Qiong;Mathias, Rasika A;Boehringer, Stefan;Mazoyer, Bernard;Rice, Ken;Cheng, Ching Yu;Maillard, Pauline;van Heemst, Diana;Wong, Tien Yin;Niessen, Wiro J;Beiser, Alexa S;Beekman, Marian;Zhao, Wanting;Nyquist, Paul A;Chen, Christopher;Launer, Lenore J;Psaty, Bruce M;Ikram, M Kamran;Vernooij, Meike W;Schmidt, Helena;Pausova, Zdenka;Becker, Diane M;De Jager, Philip L;Thompson, Paul M;van Duijn, Cornelia M;Bennett, David A;Slagboom, P Eline;Schmidt, Reinhold;Longstreth, W T;Ikram, M Arfan;Seshadri, Sudha;Debette, Stéphanie;Gudnason, Vilmundur;Adams, Hieab H H;DeCarli, Charles;
Journal Communications biology
Year 2019
DOI
10.1038/s42003-019-0537-9
URL
Keywords
classification cardiogenic shock scai

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.