Anti-Inflammatory and Antiarthritic Activities of Aqueous and Ethanolic Extracts of Cogn. (Melastomataceae) in Rats.

Clicks: 436
ID: 84008
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #2 of 32 articles by views in Evidence-based complementary and alternative medicine : eCAM

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Cogn. (Melastomataceae) is a tropical plant widely used in traditional Cameroonian medicine to relieve and treat many pathologies. It is widespread in the western region where it is used to treat typhoid fever, gastrointestinal disorders, and inflammatory diseases. The purpose of this study is to scientifically demonstrate the anti-inflammatory and antiarthritic properties of the aqueous and ethanolic extracts of the leaves of . The anti-inflammatory properties were evaluated in vitro by inhibition tests for cyclooxygenase, 5-lipoxygenase, protein denaturation, extracellular ROS production, and cell proliferation; while antiarthritic properties were evaluated in vivo in rats using the zymosan A-induced monoarthritis test and the CFA-induced polyarthritis model. This study shows that aqueous and ethanolic extracts at a concentration of 1000 g/ml inhibit the activity of cyclooxygenase (47.07% and 63.36%) and 5-lipoxygenase (66.79% and 77.7%) and protein denaturation (42.51% and 44.44%). Similarly, both extracts inhibited extracellular ROS production (IC = 5.74 g/ml and 2.96 g/ml for polymorphonuclear leukocytes, 7.47 g/ml and 3.28 g ml for peritoneal macrophages of mouse) and cell proliferation (IC = 16.89 g/ml and 3.29 g/ml). At a dose of 500 mg/kg, aqueous and ethanolic extracts significantly reduce edema induced by zymosan A (69.30% and 81.80%) and CFA (71.85% and 79.03%). At the same dose, both extracts decreased sensitivity to mechanical hyperalgesia with 69.00% and 70.35% inhibition, respectively. Systemic and histological analyzes show that both extracts maintain the studied parameters very close to normal and greatly restored the normal architecture of the joint in animals. would therefore be a very promising source for the treatment of inflammatory diseases.
Reference Key
djuichou-nguemnang2019evidencebased Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Djuichou Nguemnang, Stephanie Flore;Tsafack, Eric Gonzal;Mbiantcha, Marius;Gilbert, Ateufack;Atsamo, Albert Donatien;Yousseu Nana, William;Matah Marthe Mba, Vanessa;Adjouzem, Carine Flore;
Journal Evidence-based complementary and alternative medicine : eCAM
Year 2019
DOI
10.1155/2019/3612481
URL
Keywords
inflammation salmonella typhoid adhesion epithelial cells

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.